XpressGT®: Revolutionizing Biomarker Quantification
Simple, Scalable, and Cost-effective 2-Hydroxybutyrate Measurement.
A Key Biomarker in Diabetes and Beyond
The Importance of
2-Hydroxybutyrate (2-HB)
2-hydroxybutyrate (alpha-hydroxybutyrate) is a well-established biomarker in the diabetes arena and beyond. It correlates with insulin resistance, impaired glucose tolerance in prediabetics, and gestational diabetes. 2-HB is uniquely positioned for screening gestational diabetes and prediabetes with high sensitivity. Applications beyond the diabetes arena include testing for endometriosis and liver disease.
Insuline Resistance
α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population
Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
Impaired glucose
α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance
Gestational diabetes
Metabolomic and genetic architecture of gestational diabetes subtypes
Gas Chromatography–Mass Spectroscopy-Based Metabolomics Analysis Reveals Potential Biochemical Markers for Diagnosis of Gestational Diabetes Mellitus
GLP-1 analoga monitoring
Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes
Endometriosis
A comprehensive multiplatform metabolomic analysis reveals alterations of 2-hydroxybutyric acid among women with deep endometriosis related to the pesticide trans-nonachlor
Liver disease
Hepatic NADH reductive stress underlies common variation in metabolic traits
Complexity and Cost
The Challenge with Current Methods
Currently, three methods are available for the quantification of 2-hydroxybutyrate: LC-MS, GC-MS, and NMR. These methods are costly, hard to set up, and thus only available in specialized labs or core facilities. No big datasets can be measured, which is essential for biomarker discovery and validation.
Fasting Requirements
Poor Repeatability
Unpleasant Experience
Higher Labor Costs
Duration: 2-3 h
False Positive Results
Streamlining Biomarker Analysis
Introducing XpressGT®
XpressGT® is a disruptive solution to quantify the promising biomarker 2-hydroxybutyrate (alpha-hydroxybutyrate). Current methods for quantification of 2-HB are expensive and complex, but XpressGT® changes the game by enabling simple, high-throughput analysis in every lab.
Simplifying 2-Hydroxybutyrate Quantification
Why choose XpressGT®
XpressGT® enables simple high-throughput analysis of 2-hydroxybutyrate in every lab. Available for photometric platereaders and clinical chemistry analyzers, XpressGT® offers fast results with a simple protocol. It is validated in human serum and plasma samples and is robust against interferents.
From Diabetes to Endometriosis
Clinical Applications
Currently, three methods are available for the quantification of 2-hydroxybutyrate: LC-MS, GC-MS, and NMR. These methods are costly, hard to set up, and thus only available in specialized labs or core facilities. No big datasets can be measured, which is essential for biomarker discovery and validation.
A Superior Alternative
XpressGT® vs. Oral Glucose Tolerance Test (OGTT)
The OGTT is an established diagnostic procedure for diabetes testing, known for its high sensitivity. However, it is unpopular due to its cost and complexity, leading to underestimation of diabetes and late treatment. XpressGT® offers a novel, enzymatic test with colorimetric readout that provides results in just 8 minutes, making it a practical and efficient alternative.
Results in 8 min
Fits Routine Blood Draws
Interference Resistance
Clinical Analyzer Compatible
Serum and Plasma Validated
Patent Protected
Get Started with XpressGT® Today
Ready to Transform Your Lab?
Discover how XpressGT® can revolutionize your biomarker analysis. Contact us for more information and to place your order.